Probiotic science has long faced a frustrating challenge: the leap from lab dish to human body is rarely straightforward. Traditional in vitro cultures can’t capture the complexity of living tissues, and animal models often fall short in representing human-specific physiology. In recent years, however, a breakthrough has been reshaping this landscape—organ-on-a-chip systems that recreate human organ
In the world of neuroscience, where the human brain remains one of the last great frontiers, scientists have long grappled with a fundamental challenge: how to model complex, human-specific neurological disorders in animals that are fundamentally different from us. Over the past decade, a quiet revolution has taken shape in the form of humanized mouse
Over the past few decades, monoclonal antibodies have become some of the most successful biotechnology drugs, particularly in hematology, oncology, autoimmune disorders, and infectious diseases. While IgG antibodies dominate current cancer therapies, non-IgG antibodies such as IgA, IgE, and IgY are gaining attention for their unique biological properties and therapeutic potential. These antibodies provide alternative
Cancer development is not just about uncontrolled cell growth; it’s a complex interplay between the tumor cells, their surrounding environment, and the body’s immune system. Three key factors — Interleukin-6 (IL-6), B-cell lymphoma 2 (BCL2), and natural killer (NK) cells — are central to this dynamic process, each influencing tumor progression and the body’s defense
Extracellular vesicles (EVs), particularly exosomes, have emerged as vital mediators of intercellular communication. Among their diverse molecular cargos, RNA molecules represent a particularly rich source of biological information. Sequencing exosomal RNA provides unique opportunities to decode cellular activity, uncover disease biomarkers, and advance therapeutic development. While whole transcriptome sequencing offers a broad view, specialized sequencing
The advent of BRAF inhibitors and immune checkpoint inhibitors (ICIs) has significantly improved the prognosis of melanoma patients. However, melanoma subtypes such as limbal, mucosal, and uveal melanomas are less responsive to these therapies than cutaneous melanomas, and new therapeutic agents are urgently needed for treatment-resistant patients. Antibody-drug conjugates (ADCs) achieve targeted killing of tumor cells
The biological landscape inside tissues is remarkably complex. Cells are not only diverse in type and function but are also spatially arranged in highly organized patterns that dictate their interactions and behaviors. While traditional single-cell technologies provide valuable insights into cellular states, they often miss the spatial context that defines how cells function in real
Throughout human history, the immune system has been our greatest defense against viral threats. As a cornerstone of the innate immune system, Natural Killer (NK) cells have emerged as a game-changer in antiviral research due to their unique ability to recognize and eliminate infected cells without prior exposure. From COVID-19 to influenza and HIV, NK
Next-generation sequencing (NGS) has become a pivotal technology in cancer diagnostics, offering exceptional sensitivity, throughput, and cost efficiency. By enabling comprehensive genomic analysis, NGS has transformed how cancer is understood and detected. Advanced platforms now integrate technologies such as Whole Exome Sequencing (WES) and Circle-Seq-based eccDNA identification, providing researchers with powerful tools to unravel the complexity
Don’t Miss Out: August 22, 12 PM EDT! Mark your calendar now—August 22, 2025 at 12 PM EDT—for an exclusive live webinar hosted by Creative Biolabs, spotlighting the revolutionary tumoroid-on-a-chip technology for cancer immunotherapy research. This highly anticipated session, titled “Tumoroid-on-a-Chip as a Physiologically Relevant Model for Immunotherapy,” will be led by Dr. Mohsen Akbari,